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Antimicrobial Agents and Chemotherapy, November 2004, p. 4450-4452, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4450-4452.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Antimicrobial and Antileishmanial Activities of Hypocrellins A and B

Guoyi Ma,1 Shabana I. Khan,1 Melissa R. Jacob,1 Babu L. Tekwani,1 Zuqiang Li,2 David S. Pasco,1,3 Larry A. Walker,1,4 and Ikhlas A. Khan1,3*

National Center for Natural Products Research,1 Department of Pharmacognosy,3 Department of Pharmacology, School of Pharmacy, The University of Mississippi, University, Mississippi,4 Experimental Center, Yunnan University, Kunming, People's Republic of China2

Received 18 March 2004/ Returned for modification 22 June 2004/ Accepted 19 July 2004

Hypocrellins A and B were evaluated for in vitro antimicrobial and antileishmanial activities. Hypocrellin A exhibited promising activity against Candida albicans and moderate activity against Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Hypocrellin B showed weak antimicrobial activities. Hypocrellin A exhibited potent antileishmanial activity, while hypocrellin B was only moderately active. These results of promising antifungal and antileishmanial activity of hypocrellin A may be useful for further structure-activity relationship and in vivo studies.

* Corresponding author. Mailing address: The National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677. Phone: (662) 915-7821. Fax: (662) 915-7989. E-mail: ikhan{at}olemiss.edu.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4450-4452, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4450-4452.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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