This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Di Bonaventura, G.
Right arrow Articles by Piccolomini, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Di Bonaventura, G.
Right arrow Articles by Piccolomini, R.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, November 2004, p. 4453-4456, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4453-4456.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Pharmacodynamic Characteristics of Amphotericin B, Caspofungin, Fluconazole, and Voriconazole against Bloodstream Isolates of Infrequent Candida Species from Patients with Hematologic Malignancies

Giovanni Di Bonaventura,1,2 Ilaria Spedicato,1,2 Carla Picciani,1,2 Domenico D'Antonio,3 and Raffaele Piccolomini1,2*

Department of Biomedical Sciences, Laboratory of Clinical Microbiology"G. d’Annunzio" University,1 Aging Research Center, Ce.S.I., "G. D'Annunzio" University Foundation, Chieti-Pescara,2 Clinical Microbiology Service, Department of Hematology and Oncology, "Spirito Santo" Hospital, Pescara, Italy3

Received 27 February 2004/ Returned for modification 24 May 2004/ Accepted 25 July 2004

Time-kill and postantifungal effect (PAFE) of amphotericin B, caspofungin, fluconazole, and voriconazole were determined against clinical isolates of Candida guilliermondii, Candida kefyr, and Candida lusitaniae. Azoles displayed fungistatic activity and no measurable PAFE, regardless of the concentration tested. Amphotericin B and caspofungin demonstrated concentration-dependent fungicidal activity, although amphotericin B only produced a significant dose-dependent PAFE against all isolates tested.

* Corresponding author. Mailing address: Center of Excellence on Aging, Room 27, 5th level, "G. D'Annunzio" University, Via Colle dell'Ara, 66100 Chieti, Italy. Phone: (39) 0871 54 15 19. Fax: (39) 0871 355 52 82. E-mail: r.piccolomini{at}dsb.unich.it.

Antimicrobial Agents and Chemotherapy, November 2004, p. 4453-4456, Vol. 48, No. 11
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.11.4453-4456.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Li, Y., Nguyen, M. H., Derendorf, H., Cheng, S., Clancy, C. J. (2007). Measurement of Voriconazole Activity against Candida albicans, C. glabrata, and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography. Antimicrob. Agents Chemother. 51: 2985-2987 [Abstract] [Full Text]  
  • Barchiesi, F., Spreghini, E., Tomassetti, S., Della Vittoria, A., Arzeni, D., Manso, E., Scalise, G. (2006). Effects of Caspofungin against Candida guilliermondii and Candida parapsilosis.. Antimicrob. Agents Chemother. 50: 2719-2727 [Abstract] [Full Text]  
  • Clancy, C. J., Huang, H., Cheng, S., Derendorf, H., Nguyen, M. H. (2006). Characterizing the Effects of Caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata Isolates by Simultaneous Time-Kill and Postantifungal-Effect Experiments.. Antimicrob. Agents Chemother. 50: 2569-2572 [Abstract] [Full Text]  
  • Rukayadi, Y., Yong, D., Hwang, J.-K. (2006). In vitro anticandidal activity of xanthorrhizol isolated from Curcuma xanthorrhiza Roxb. J Antimicrob Chemother 57: 1231-1234 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»