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Antimicrobial Agents and Chemotherapy, December 2004, p. 4650-4653, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4650-4653.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Pharmacokinetics of Telithromycin in Plasma and Soft Tissues after Single-Dose Administration to Healthy Volunteers

Rainer Gattringer,1,2 Eleonora Urbauer,1 Friederike Traunmüller,1 Markus Zeitlinger,1 Pejman Dehghanyar,1 Petra Zeleny,1 Wolfgang Graninger,2 Markus Müller,1 and Christian Joukhadar1,3*

,1 Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics,2 Institute of Pharmacology, Medical University of Vienna, Vienna, Austria3

Received 24 May 2004/ Returned for modification 26 July 2004/ Accepted 29 August 2004

By use of microdialysis we assessed the concentrations of telithromycin in muscle and adipose tissue to test its ability to penetrate soft tissues. The ratios of the area under the concentration-versus-time curve from 0 to 24 h to the MIC indicated that free concentrations of telithromycin in tissue and plasma might be effective against Streptococcus pyogenes but not against staphylococci and human and animal bite pathogens.

* Corresponding author. Mailing address: Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. Phone: 43-1-40400-2981. Fax: 43-1-40400-2998. E-mail: christian.joukhadar{at}meduniwien.ac.at.

Antimicrobial Agents and Chemotherapy, December 2004, p. 4650-4653, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4650-4653.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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  • Schmidt, S., Banks, R., Kumar, V., Rand, K. H., Derendorf, H. (2008). Clinical Microdialysis in Skin and Soft Tissues: An Update. J Clin Pharmacol 48: 351-364 [Abstract] [Full Text]  
  • Dehghanyar, P., Burger, C., Zeitlinger, M., Islinger, F., Kovar, F., Muller, M., Kloft, C., Joukhadar, C. (2005). Penetration of Linezolid into Soft Tissues of Healthy Volunteers after Single and Multiple Doses. Antimicrob. Agents Chemother. 49: 2367-2371 [Abstract] [Full Text]  
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