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Antimicrobial Agents and Chemotherapy, December 2004, p. 4922-4925, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4922-4925.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus Isolates from Transplant and Nontransplant Patients

William J. Steinbach,1* Nina Singh,2 Jackie L. Miller,3 Daniel K. Benjamin Jr.,1,4 Wiley A. Schell,3 Joseph Heitman,5,6,7 and John R. Perfect3

Division of Pediatric Infectious Diseases, Department of Pediatrics,1 Division of Infectious Diseases and International Health, Department of Medicine,3 Duke Clinical Research Institute,4 Department of Molecular Genetics and Microbiology,5 Department of Pharmacology and Cancer Biology,6 Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina,7 Infectious Disease Section, Veterans Affairs Medical Center, University of Pittsburgh, Thomas E. Stanzel Transplantation Institute, Pittsburgh, Pennsylvania2

Received 1 June 2004/ Returned for modification 5 July 2004/ Accepted 3 August 2004

We performed in vitro antifungal checkerboard testing on 12 Aspergillus fumigatus clinical isolates (6 transplant recipients and 6 nontransplant patients) with three antifungal agents (amphotericin B, voriconazole, and caspofungin) and three immunosuppressants (FK506, cyclosporine, and rapamycin). We were not able to detect a difference in calcineurin inhibitor antifungal activity against isolates from transplant recipients and nontransplant patients.

* Corresponding author. Mailing address: Division of Pediatric Infectious Diseases, Box 3499, Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-6335. Fax: (919) 684-8902. E-mail: stein022{at}mc.duke.edu.

Antimicrobial Agents and Chemotherapy, December 2004, p. 4922-4925, Vol. 48, No. 12
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.12.4922-4925.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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