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Antimicrobial Agents and Chemotherapy, February 2004, p. 615-618, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.615-618.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

fexA, a Novel Staphylococcus lentus Gene Encoding Resistance to Florfenicol and Chloramphenicol

Corinna Kehrenberg and Stefan Schwarz*

Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, 31535 Neustadt-Mariensee, Germany

Received 23 April 2003/ Returned for modification 21 September 2003/ Accepted 19 October 2003

The Staphylococcus lentus plasmid pSCFS2 carries a novel florfenicol-chloramphenicol resistance gene, designated fexA, encoding a protein of 475 amino acids with 14 transmembrane domains. The FexA protein differs from all previously known proteins involved in the efflux of chloramphenicol and florfenicol. Induction of fexA expression by chloramphenicol and florfenicol occurs via translational attenuation.

* Corresponding author. Mailing address: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, Höltystr. 10, 31535 Neustadt-Mariensee, Germany. Phone: 49-5034-871242. Fax: 49-5034-871246. E-mail: stefan.schwarz{at}fal.de.

Antimicrobial Agents and Chemotherapy, February 2004, p. 615-618, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.615-618.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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