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Antimicrobial Agents and Chemotherapy, February 2004, p. 619-622, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.619-622.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Ribosomal Alterations Contribute to Bacterial Resistance against the Dipeptide Antibiotic TAN 1057

E. Limburg, R. Gahlmann, H.-P. Kroll, and D. Beyer*

Department of Antiinfectives, Pharma Research, Bayer Health Care AG, D-42096 Wuppertal, Germany

Received 20 June 2003/ Returned for modification 26 August 2003/ Accepted 23 October 2003

TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations in the ribosomes contribute to the resistance of the bacteria.

* Corresponding author. Mailing address: Bayer AG, Pharma Research Center, Aprather Weg 18a, D-42096 Wuppertal, Germany. Phone: (49) 202-364190. Fax: (49) 202-364116. E-mail: dieter.beyer.db{at}bayer-ag.de.

Antimicrobial Agents and Chemotherapy, February 2004, p. 619-622, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.619-622.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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