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Antimicrobial Agents and Chemotherapy, February 2004, p. 626-628, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.626-628.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Class 1 Integron Containing Metallo-ß-Lactamase Gene blaVIM-2 in Pseudomonas aeruginosa Clinical Strains Isolated in Japan

Jun Yatsuyanagi,1* Shioko Saito,1 Seizaburo Harata,1 Noriyuki Suzuki,1 Yuko Ito,2 Ken-ichi Amano,3 and Katsuhiko Enomoto4

Akita Prefectural Institute of Public Health, 6-6 Sensyu kubota-machi, Akita 010-0874,1 Akita Kumiai General Hospital, 273-1 Iijima aza nishibukuro, Akita 011-0911,2 Central Research Laboratory,3 Department of Pathology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan4

Received 8 July 2003/ Returned for modification 2 October 2003/ Accepted 22 October 2003

Four blaVIM-2 gene-harboring Pseudomonas aeruginosa strains were identified. These strains possessed a class 1 integron harboring ORF1, blaVIM-2, and aacA4 gene cassettes. The transposon-mediated horizontal spread of the blaVIM-2 gene among these strains was suggested, which increases the threat that the blaVIM-2 gene will disseminate among diverse genera of bacteria.

* Corresponding author. Mailing address: Akita Prefectural Institute of Public Health, 6-6 Sensyu kubota-machi, Akita 010-0874, Japan. Phone: 81-18-832-5005. Fax: 81-18-832-5938. E-mail: jyatsu{at}spica.freemail.ne.jp.

Antimicrobial Agents and Chemotherapy, February 2004, p. 626-628, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.626-628.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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