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Antimicrobial Agents and Chemotherapy, February 2004, p. 638-640, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.638-640.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Moxifloxacin Penetration in Bronchial Secretions of Mechanically Ventilated Patients with Pneumonia

Marc Leone,1* Jacques Albanèse,1 Emmanuelle Sampol-Manos,2 Nicolas Simon,2 Bruno Lacarelle,2 Bernard Bruguerolle,2 and Claude Martin1

Department of Anesthesiology and Intensive Care Unit and Trauma Center, Nord Hospital,1 Department of Pharmacokinetics, Timone Hospital, Marseilles School of Medicine, Marseilles, France2

Received 14 July 2003/ Returned for modification 24 August 2003/ Accepted 14 October 2003

The pharmacokinetics of moxifloxacin was studied in 17 mechanically ventilated patients with pneumonia. Patients were given 400 mg of moxifloxacin intravenously. Blood samples and bronchial secretions were taken on days 1 and 4. A dose of 400 mg of moxifloxacin allows one to achieve efficient concentrations in bronchial secretions and plasma.

* Corresponding author. Mailing address: Département d'Anesthésie et de Réanimation, CHU Nord, 13915 Marseille cedex 20, France. Phone: 33491968650. Fax: 33491962818. E-mail: leonem{at}msnotes.wustl.edu.

Antimicrobial Agents and Chemotherapy, February 2004, p. 638-640, Vol. 48, No. 2
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.2.638-640.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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