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Antimicrobial Agents and Chemotherapy, March 2004, p. 1007-1011, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1007-1011.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of Daptomycin against Gram-Positive European Clinical Isolates with Defined Resistance Determinants

Ad C. Fluit,* Franz-Josef Schmitz, Jan Verhoef, and Dana Milatovic

Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands

Received 23 August 2003/ Returned for modification 18 September 2003/ Accepted 10 November 2003

The in vitro activity of daptomycin against 337 gram-positive European clinical isolates with known resistance genes was determined. The MIC ranges for Staphylococcus aureus, enterococci, pneunococci, and streptococci were 0.03 to 1, 0.25 to 8, 0.12 to 1, and 0.06 to 8 µg/ml, respectively. For only one streptococcus isolate and seven enterococcus isolates was the MIC 8 µg/ml.

* Corresponding author. Mailing address: Eijkman-Winkler Institute for Microbiology, Infectious Diseases, and Inflammation, University Medical Center Utrecht, Room G 04.614, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Phone: 31 30 250 7630. Fax: 31 30 254 1770. E-mail: A.C.Fluit{at}lab.azu.nl.

Antimicrobial Agents and Chemotherapy, March 2004, p. 1007-1011, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1007-1011.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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