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Antimicrobial Agents and Chemotherapy, March 2004, p. 1040-1042, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1040-1042.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Selection during Cefepime Treatment of a New Cephalosporinase Variant with Extended-Spectrum Resistance to Cefepime in an Enterobacter aerogenes Clinical Isolate

G. Barnaud,1,2* Y. Benzerara,1 J. Gravisse,2 L. Raskine,2 M. J. Sanson-Le Pors,2 R. Labia,3 and G. Arlet1

Service de Bactériologie, Hôpital Tenon AP-HP,1 Service de Bactériologie-Virologie, Hôpital Lariboisière AP-HP, Paris,2 CNRS-UBO-MNHN, Unité FRE 2125, Quimper, France3

Received 23 May 2003/ Returned for modification 22 July 2003/ Accepted 11 November 2003

Enterobacter aerogenes resistant to cefepime (MIC, 32 µg/ml) was isolated from a patient treated with cefepime for an infection caused by a strain of E. aerogenes overproducing its AmpC ß-lactamase (MIC of cefepime, 0.5 µg/ml). The AmpC ß-lactamase of the resistant strain had an L-293-P amino acid substitution and a high kcat/Km ratio for cefepime. Both of these modifications were necessary for resistance to cefepime.

* Corresponding author. Mailing address: Service de Microbiologie et Hygiène, Hôpital Louis-Mourier AP-HP, 178 rue des Renouillers, 92701 Colombes Cedex, France. Phone: 33 1 47 60 60 10. Fax: 33 1 47 60 60 48. E-mail: guilene.barnaud{at}lmr.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, March 2004, p. 1040-1042, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1040-1042.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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