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Antimicrobial Agents and Chemotherapy, March 2004, p. 1055-1057, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1055-1057.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Synergistic Activities of Moxifloxacin Combined with Piperacillin-Tazobactam or Cefepime against Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii Clinical Isolates

Rose Jung,* Maroof Husain, Michael K. Choi, and Douglas N. Fish

Antimicrobial Research Laboratory, Department of Clinical Pharmacy, University of Colorado Health Sciences Center, Denver, Colorado 80262

Received 14 April 2003/ Returned for modification 4 October 2003/ Accepted 5 December 2003

The bactericidal activity of moxifloxacin alone and in combination with cefepime or piperacillin-tazobactam against clinical isolates of Klebsiella pneumoniae, Enterobacter cloacae, and Acinetobacter baumannii was evaluated by using time-kill methods and antimicrobial concentrations of one-half and one times the MIC. Synergy was observed in 58 to 88% of the strains and resulted in bactericidal activity against 60 to 100% of the strains. Combinations including moxifloxacin demonstrated enhanced bactericidal activity compared with that of either agent tested alone.

* Corresponding author. Mailing address: University of Colorado Health Sciences Center, Department of Clinical Pharmacy, School of Pharmacy, 4200 East Ninth Ave., Campus Box C-238, Denver, CO 80262. Phone: (303) 315-2664. Fax: (303) 315-4630. E-mail: rose.jung{at}uchsc.edu.

Antimicrobial Agents and Chemotherapy, March 2004, p. 1055-1057, Vol. 48, No. 3
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.3.1055-1057.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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