This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sato, Y.
Right arrow Articles by Higuti, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sato, Y.
Right arrow Articles by Higuti, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, April 2004, p. 1357-1360, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1357-1360.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

6,7-Dihydroxyflavone Dramatically Intensifies the Susceptibility of Methicillin-Resistant or -Sensitive Staphylococcus aureus to ß-Lactams

Youichi Sato, Hirofumi Shibata, Naokatu Arakaki, and Tomihiko Higuti*

Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan

Received 27 August 2003/ Returned for modification 11 November 2003/ Accepted 19 December 2003

We have demonstrated that 6,7-dihydroxyflavone by itself has only a weak antibacterial effect on methicillin-resistant Staphylococcus aureus (MRSA) but that at concentrations less than MIC it synergistically elevates the susceptibility of clinically isolated MRSA and methicillin-sensitive S. aureus strains to ß-lactam antibiotics from 8- to 32,800-fold.

* Corresponding author. Mailing address: Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78 Shomachi, Tokushima 770-8505, Japan. Phone: 81-88-633-7254. Fax: 81-88-633-9550. E-mail: thiguti{at}ph.tokushima-u.ac.jp.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1357-1360, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1357-1360.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Shibata, H., Kondo, K., Katsuyama, R., Kawazoe, K., Sato, Y., Murakami, K., Takaishi, Y., Arakaki, N., Higuti, T. (2005). Alkyl Gallates, Intensifiers of {beta}-Lactam Susceptibility in Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 49: 549-555 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»