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Antimicrobial Agents and Chemotherapy, April 2004, p. 1400-1401, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1400-1401.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Activities of Newer Quinolones against Escherichia coli and Klebsiella pneumoniae Containing the Plasmid-Mediated Quinolone Resistance Determinant qnr

Minggui Wang,1,2 Daniel F. Sahm,3 George A. Jacoby,4 Yingyuan Zhang,2 and David C. Hooper1*

Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114,1 Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China,2 Focus Technologies, Herndon, Virginia 20171,3 Infectious Disease Department, Lahey Clinic, Burlington, Massachusetts 018054

Received 10 October 2003/ Returned for modification 19 December 2003/ Accepted 30 December 2003

Seventeen qnr-containing transconjugants were constructed with azide-resistant Escherichia coli J53 as the recipient, and the MICs of 12 quinolones were tested by agar dilution methods. Sitafloxacin, BAYy3118, and premafloxacin had higher activity in vitro than ciprofloxacin against transconjugants and donors containing qnr. The donors had higher quinolone MICs than the transconjugants.

* Corresponding author. Mailing address: Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114-2696. Phone: (617) 726-3812. Fax: (617) 726-7416. E-mail: dhooper{at}partners.org.

Antimicrobial Agents and Chemotherapy, April 2004, p. 1400-1401, Vol. 48, No. 4
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.4.1400-1401.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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