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Antimicrobial Agents and Chemotherapy, June 2004, p. 2280-2282, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2280-2282.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Activity of OPT-80 against Clostridium difficile

Grit Ackermann,* Birgit Löffler, Daniela Adler, and Arne C. Rodloff

Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, 04103 Leipzig, Germany

Received 9 December 2003/ Returned for modification 26 January 2004/ Accepted 11 February 2004

Clostridium difficile remains the major cause of nosocomial diarrhea. Reports on impaired susceptibility of C. difficile to metronidazole and vancomycin and frequent relapses of patients after therapy necessitate the search for new substances. With this study, the activity of OPT-80, a new macrocycle, against 207 C. difficile strains and against other obligately anaerobic bacteria was tested. OPT-80 showed high in vitro activity against all C. difficile strains tested.

* Corresponding author. Mailing address: Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstrasse 24, 04103 Leipzig, Germany. Phone: 49 341 9715200. Fax: 49 341 9715209. E-mail: ackermg{at}medizin.uni-leipzig.de.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2280-2282, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2280-2282.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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