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Antimicrobial Agents and Chemotherapy, June 2004, p. 2288-2291, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2288-2291.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Posaconazole Therapy of Disseminated Phaeohyphomycosis in a Murine Model

John R. Graybill,1 Laura K. Najvar,1* Elizabeth Johnson,2 Rosie Bocanegra,1 and David Loebenberg3

Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900,1 Public Health Service Mycology Reference Laboratory, Bristol, United Kingdom,2 Schering-Plough Research Institute, Kenilworth, New Jersey 07033-13003

Received 18 July 2003/ Returned for modification 18 August 2003/ Accepted 20 February 2004

Immunocompetent (nu/+) and athymic (nu/nu) BALB/c mice were infected intravenously with Wangiella dermatitidis and treated with posaconazole. Posaconazole reduced the counts in tissues and prolonged survival. Of particular interest, posaconazole reduced the counts of this neurotropic pathogen in the brain.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, Medicine/ID Mail Code 7881, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229-3900. Phone: (210) 567-0990. Fax: (210) 567-0962. E-mail: najvar{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, June 2004, p. 2288-2291, Vol. 48, No. 6
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.6.2288-2291.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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