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Antimicrobial Agents and Chemotherapy, July 2004, p. 2693-2696, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2693-2696.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide

Chang-Jer Wu,1,{dagger} Jia-Tsrong Jan,1,{dagger} Chi-Min Chen,2 Hsing-Pang Hsieh,3 Der-Ren Hwang,3 Hwan-Wun Liu,1 Chiu-Yi Liu,1 Hui-Wen Huang,1 Su-Chin Chen,1 Cheng-Fong Hong,1 Ren-Kuo Lin,3 Yu-Sheng Chao,3 and John T. A. Hsu3*

Institute of Preventive Medicine, National Defense Medical College, National Defense University,1 Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Taipei,3 Animal Technology Institute Taiwan, Miaoli, Taiwan2

Received 17 November 2003/ Returned for modification 21 January 2004/ Accepted 20 February 2004

Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 µM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.

* Corresponding author. Mailing address: Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 128 Yen-Chiu-Yuan Rd., Sec. 2, Taipei, Taiwan. Phone: 886-2-2652-4135. Fax: 886-2-2789-0264. E-mail: tsuanhsu{at}nhri.org.tw.

{dagger} C.-J.W. and J.-T.J. contributed equally to this work.

Antimicrobial Agents and Chemotherapy, July 2004, p. 2693-2696, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2693-2696.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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