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Antimicrobial Agents and Chemotherapy, July 2004, p. 2700-2703, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2700-2703.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Constitutive Activation of the PDR16 Promoter in a Candida albicans Azole-Resistant Clinical Isolate Overexpressing CDR1 and CDR2

Xavier De Deken and Martine Raymond*

Institut de Recherches Cliniques de Montréal, Montréal, Québec, Canada H2W 1R7

Received 4 December 2003/ Returned for modification 7 January 2004/ Accepted 8 March 2004

Candida albicans azole-resistant clinical isolates overexpressing the CDR1 and CDR2 genes (multidrug transporters) also overexpress the PDR16 gene (phosphatidylinositol transfer protein). We show here that the PDR16 promoter displays higher transcriptional activity following integration in an azole-resistant isolate than in the matched azole-susceptible one. Thus, the upregulation of PDR16 in the resistant strain results from a mutation acting in trans.

* Corresponding author. Mailing address: Institut de Recherches Cliniques de Montréal, 110 Pine Ave. West, Montréal, Québec, Canada H2W 1R7. Phone: 514-987-5770. Fax: 514-987-5764. E-mail: raymonm{at}ircm.qc.ca.

Antimicrobial Agents and Chemotherapy, July 2004, p. 2700-2703, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2700-2703.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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