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Antimicrobial Agents and Chemotherapy, July 2004, p. 2727-2729, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2727-2729.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Interactions of Approved and Novel Drugs against Paecilomyces spp.

Montserrat Ortoneda,1 Javier Capilla,1 F. Javier Pastor,1 Isabel Pujol,2 Clara Yustes,1 Carolina Serena,1 and Josep Guarro1*

Unitat de Microbiologia, Facultat de Medicina,1 Laboratori de Microbiologia, Hospital Universitari de Sant Joan de Reus, Universitat Rovira i Virgili, Reus, Spain2

Received 19 February 2004/ Returned for modification 21 February 2004/ Accepted 27 February 2004

We have evaluated the in vitro activity of 15 combinations of antifungal drugs (amphotericin B, itraconazole, voriconazole, albaconazole, ravuconazole, terbinafine, and micafungin) against four isolates of Paecilomyces variotii and three of P. lilacinus. The interaction of terbinafine with the four azoles was synergistic for 53% of the combinations, while the interactions of both amphotericin B and micafungin with the rest of antifungal agents were mainly indifferent.


* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21, 43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: umb{at}fmcs.urv.es.


Antimicrobial Agents and Chemotherapy, July 2004, p. 2727-2729, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2727-2729.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.




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