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Antimicrobial Agents and Chemotherapy, July 2004, p. 2766-2770, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2766-2770.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Iodonium Salts against Oral and Dental Anaerobes

Ellie J. C. Goldstein,1,2* Diane M Citron,1 Yumi Warren,1 C. Vreni Merriam, Kerin Tyrrell,1 Helen Fernandez,1 Ukkiramapandian Radhakrishnan,3 Peter J. Stang, and Georg Conrads4

R. M. Alden Research Laboratory, Santa Monica, California 90404,1 UCLA School of Medicine, Los Angeles, California 90024,2 Department of Chemistry, University of Utah, Salt Lake City, Utah 84112,3 Division of Oral Microbiology and Immunology, Department of Operative and Preventative Dentistry and Periodontology, University Hospital of Aachen (RWTH), Aachen, Germany4

Received 2 December 2003/ Returned for modification 26 February 2004/ Accepted 17 March 2004

The comparative in vitro activities of 11 iodonium salt compounds, 0.12% chlorhexidine, and four antimicrobial agents against 322 anaerobic and fastidious potential dental and periodontal bacterial pathogens were studied. Iodonium salts 3, 4, 5, 9, and 10 had in vitro activities comparable to that of chlorhexidine against most isolates. These compounds may be suitable for incorporation into an oral mouthwash.

* Corresponding author. Mailing address: R. M. Alden Research Laboratory, 2021 Santa Monica Blvd., Suite 740 E, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: ejcgmd{at}aol.com.

Antimicrobial Agents and Chemotherapy, July 2004, p. 2766-2770, Vol. 48, No. 7
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.7.2766-2770.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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