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Antimicrobial Agents and Chemotherapy, August 2004, p. 3130-3132, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3130-3132.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Killing of Mycobacterium ulcerans by Acidified Nitrite

R. Phillips,1,2,3* S. Kuijper,3 N. Benjamin,4 M. Wansbrough-Jones,2 M. Wilks,5 and A. H. J. Kolk3

Komfo Anokye Teaching Hospital, Kumasi, Ghana,1 St. George's Hospital Medical School,2 Department of Medical Microbiology, St. Bartholomew's Hospital, London,5 Peninsula Medical School, St. Luke's Campus, Exeter, United Kingdom,4 KIT Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands3

Received 1 December 2003/ Returned for modification 30 January 2004/ Accepted 26 April 2004

Mycobacterium ulcerans, which causes Buruli ulcer, was exposed to acidified nitrite or to acid alone for 10 or 20 min. Killing was rapid, and viable counts were reduced below detectable limits within 10 min of exposure to 40 mM acidified nitrite. M. ulcerans is highly susceptible to acidified nitrite in vitro.

* Corresponding author. Mailing address: Department of Cellular and Molecular Medicine (Infectious Diseases), St. George's Hospital Medical School, London SW17 0RE, United Kingdom. Phone: 44 208 725 5830. Fax: 44 208 725 3487. E-mail: rphillip{at}sghms.ac.uk.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3130-3132, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3130-3132.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mortensen, H. D., Jacobsen, T., Koch, A. G., Arneborg, N. (2008). Intracellular pH Homeostasis Plays a Role in the Tolerance of Debaryomyces hansenii and Candida zeylanoides to Acidified Nitrite. Appl. Environ. Microbiol. 74: 4835-4840 [Abstract] [Full Text]  
  • Wansbrough-Jones, M., Phillips, R. (2005). Buruli ulcer. BMJ 330: 1402-1403 [Full Text]  
  • Phillips, R., Adjei, O., Lucas, S., Benjamin, N., Wansbrough-Jones, M. (2004). Pilot Randomized Double-Blind Trial of Treatment of Mycobacterium ulcerans Disease (Buruli Ulcer) with Topical Nitrogen Oxides. Antimicrob. Agents Chemother. 48: 2866-2870 [Abstract] [Full Text]  


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