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Antimicrobial Agents and Chemotherapy, August 2004, p. 3162-3164, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3162-3164.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Temporin A Soaking in Combination with Intraperitoneal Linezolid Prevents Vascular Graft Infection in a Subcutaneous Rat Pouch Model of Infection with Staphylococcus epidermidis with Intermediate Resistance to Glycopeptides

Andrea Giacometti,1* Oscar Cirioni,1 Roberto Ghiselli,2 Fiorenza Orlando,3 Giuseppina D'Amato,1 Wojciech Kamysz,4 Federico Mocchegiani,2 Valerio Sisti,2 Carmela Silvestri,1 Jerzy Lukasiak,4 Marco Rocchi,5 Vittorio Saba,2 and Giorgio Scalise1

Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche,1 Department of General Surgery, I.N.R.C.A. I.R.C.C.S., Università Politecnica delle Marche,2 Biotechnology Centre, Research Department, I.N.R.C.A. I.R.C.C.S., Ancona,3 Institute of Biomathematics, Faculty of Pharmacy, University of Urbino, Urbino, Italy,5 Faculty of Pharmacy, Medical University of Gdask, Gdask, Poland4

Received 1 April 2004/ Returned for modification 3 April 2004/ Accepted 5 April 2004

The efficacy of linezolid and temporin A in the prevention of prosthetic graft infection due to methicillin-resistant Staphylococcus epidermidis with intermediate resistance to glycopeptides was investigated in a subcutaneous rat pouch model. Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs.

* Corresponding author. Mailing address: Clinica Malattie Infettive, c/o Ospedale Regionale, via Conca, 60020 Ancona, Italy. Phone: 39 071 5963715. Fax: 39 071 5963468. E-mail: anconacmi{at}interfree.it.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3162-3164, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3162-3164.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Agalar, C., Kilic, D., Ceken, S., Ozdogan, M., Yasar, E., Ozturk, E., Baki DenkbaS, E. (2007). Inhibition of Staphylococcus Epidermidis Colonization with Fusidic Acid-Impregnated Catheters. Journal of Bioactive and Compatible Polymers 22: 160-173 [Abstract]  


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