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Antimicrobial Agents and Chemotherapy, August 2004, p. 3169-3171, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3169-3171.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

In Vitro Activities of Telithromycin, Linezolid, and Quinupristin-Dalfopristin against Streptococcus pneumoniae with Macrolide Resistance Due to Ribosomal Mutations

David J. Farrell,* Ian Morrissey, Sarah Bakker, Sylvie Buckridge, and David Felmingham

GR Micro Ltd., London, United Kingdom

Received 23 November 2003/ Returned for modification 1 March 2004/ Accepted 3 April 2004

To date, 86 of 7,746 macrolide-resistant Streptococcus pneumoniae isolates from 1999 to 2002 PROTEKT (Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin) surveillance studies were negative for methylase and efflux mechanisms. Mutations in 23S rRNA or the genes encoding riboprotein L4 or L22 were found in 77 of 86 isolates. Six isolates were resistant to quinupristin-dalfopristin and two were resistant to linezolid, while telithromycin demonstrated good activities against all isolates.

* Corresponding author. Mailing address: GR Micro Ltd., 7-9 William Rd., London NW1 3ER, United Kingdom. Phone: 44 (0)20 73887320. Fax: 44 (0)20 73887324. E-mail: D.Farrell{at}grmicro.co.uk.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3169-3171, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3169-3171.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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