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Antimicrobial Agents and Chemotherapy, August 2004, p. 3172-3174, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3172-3174.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

CMY-13, a Novel Inducible Cephalosporinase Encoded by an Escherichia coli Plasmid

V. Miriagou,1* L. S. Tzouvelekis,1,2 L. Villa,3 E. Lebessi,1 A. C. Vatopoulos,4 A. Carattoli,3 and E. Tzelepi1

Laboratory of Bacteriology, Hellenic Pasteur Institute,1 Department of Microbiology, Medical School, University of Athens,2 Microbiology Division, National School of Public Health, Athens, Greece,4 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy3

Received 18 December 2003/ Returned for modification 14 March 2004/ Accepted 13 April 2004

An IncN plasmid (p541) from Escherichia coli carried a Citrobacter freundii-derived sequence of 4,252 bp which included an ampC-ampR region and was bound by two directly repeated IS26 elements. ampC encoded a novel cephalosporinase (CMY-13) with activity similar to that of CMY-2. AmpR was likely functional as indicated in induction experiments.

* Corresponding author. Mailing address: Laboratory of Bacteriology, Hellenic Pasteur Institute, Vas. Sofias 127, Athens 11527, Greece. Phone: 30 210 6478810. Fax: 30 210 6423498. E-mail: miriagou{at}mail.pasteur.gr.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3172-3174, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3172-3174.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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