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Antimicrobial Agents and Chemotherapy, August 2004, p. 3182-3184, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3182-3184.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

A Lipid-Peptide Microbicide Inactivates Herpes Simplex Virus

Charles E. Isaacs,* Jun Hua Jia, and Weimin Xu

New York State Institute for Basic Research in Developmental Disabilities, Department of Developmental Biochemistry, Staten Island, New York 10314

Received 3 November 2003/ Returned for modification 6 January 2004/ Accepted 29 March 2004

A microbicide combining the lipid-ether 1-0-octyl-sn-glycerol (OG; 3 mM) and peptide D2A21 (9 µM) reduced herpes simplex virus type 1 (HSV-1) and HSV-2 titers by at least 1,000-fold, more than the sum of the inactivations produced by OG and D2A21 alone. OG plus D2A21 reduced HSV-1 and HSV-2 titers by ≥1,000-fold in ≤10 and ≤20 min, respectively, whereas OG and D2A21 used alone produced almost no virus inactivation during these times.

* Corresponding author. Mailing address: Institute for Basic Research, Department of Developmental Biochemistry, 1050 Forest Hill Rd., Staten Island, NY 10314. Phone: (718) 494-5227. Fax: (718) 370-7205. E-mail: chisi{at}cunyvm.cuny.edu.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3182-3184, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3182-3184.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Moncla, B. J., Pryke, K., Isaacs, C. E. (2008). Killing of Neisseria gonorrhoeae, Streptococcus agalactiae (Group B Streptococcus), Haemophilus ducreyi, and Vaginal Lactobacillus by 3-O-Octyl-sn-Glycerol. Antimicrob. Agents Chemother. 52: 1577-1579 [Abstract] [Full Text]  
  • Isaacs, C. E., Rohan, L., Xu, W., Jia, J. H., Mietzner, T., Hillier, S. (2006). Inactivation of Herpes Simplex Virus Clinical Isolates by Using a Combination Microbicide. Antimicrob. Agents Chemother. 50: 1063-1066 [Abstract] [Full Text]  
  • Isaacs, C. E. (2005). Human Milk Inactivates Pathogens Individually, Additively, and Synergistically. J. Nutr. 135: 1286-1288 [Abstract] [Full Text]  


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