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Antimicrobial Agents and Chemotherapy, August 2004, p. 3196-3199, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3196-3199.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Novel Antimalarial Compounds Isolated in a Survey of Self-Medicative Behavior of Wild Chimpanzees in Uganda

Sabrina Krief,1 Marie-Thérèse Martin,1 Philippe Grellier,2 John Kasenene,3 and Thierry Sévenet1*

Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette Cedex,1 USM 0504, Biologie Fonctionnelle des Protozoaires, Muséum National d'Histoire Naturelle, 75231 Paris Cedex 05, France,2 Makerere University, Biological Field Station, Fort Portal, Uganda3

Received 19 December 2003/ Returned for modification 26 January 2004/ Accepted 5 April 2004

Following a veterinary and behavioral survey of chimpanzees from a natural population in Uganda, leaf samples of Trichilia rubescens were collected because of the unusual method of ingestion observed. The methanolic crude extract of T. rubescens leaves exhibited significant antimalarial activity in vitro. Bioassay-directed fractionation provided two new limonoids, trichirubines A and B. A greater understanding of the role of secondary compounds in the primate diet may be helpful in recovering naturally occurring compounds of medicinal significance for human medicine.

* Corresponding author. Mailing address: Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 1 av de la Terrasse, 91198 Gif-sur-Yvette Cedex, France. Phone: 00 33 1 69823103. E-mail: sevenet{at}icsn.cnrs-gif.fr.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3196-3199, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3196-3199.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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  • Raubenheimer, D., Simpson, S. J. (2009). Nutritional PharmEcology: Doses, nutrients, toxins, and medicines. Integr. Comp. Biol. 49: 329-337 [Abstract] [Full Text]  
  • Krief, S., Wrangham, R. W., Lestel, D. (2006). Diversity of items of low nutritional value ingested by chimpanzees from Kanyawara, Kibale National Park, Uganda: an example of the etho-ethnology of chimpanzees. Social Science Information 45: 227-263 [Abstract]  


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