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Antimicrobial Agents and Chemotherapy, August 2004, p. 3203-3206, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3203-3206.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Role of ß-Lactamases and Porins in Resistance to Ertapenem and Other ß-Lactams in Klebsiella pneumoniae

George A. Jacoby,* Debra M. Mills, and Nancy Chow

Lahey Clinic, Burlington, Massachusetts

Received 23 January 2004/ Returned for modification 6 March 2004/ Accepted 22 April 2004

High-level resistance to ertapenem was produced by ß-lactamases of groups 1, 2f, and 3 in a strain of Klebsiella pneumoniae deficient in Omp35 and Omp36. From a wild-type strain producing ACT-1 ß-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 µg/ml and expression of outer membrane proteins was diminished could be selected.

* Corresponding author. Mailing address: Lahey Clinic, 41 Mall Rd., Burlington, MA 01805. Phone: (781) 744-2928. Fax: (781) 744-5486. E-mail: george.a.jacoby{at}lahey.org.

Antimicrobial Agents and Chemotherapy, August 2004, p. 3203-3206, Vol. 48, No. 8
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.8.3203-3206.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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