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Antimicrobial Agents and Chemotherapy, September 2004, p. 3563-3566, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3563-3566.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

An Internationally Spread Clone of Streptococcus pneumoniae Evolves from Low-Level to Higher-Level Penicillin Resistance by Uptake of Penicillin-Binding Protein Gene Fragments from Nonencapsulated Pneumococci

Christoph Hauser,1 Suzanne Aebi,1 and Kathrin Mühlemann1*

Institute for Infectious Diseases, University of Berne, and University Hospital, Berne, Switzerland1

Received 25 February 2004/ Returned for modification 25 March 2004/ Accepted 19 May 2004

Low-level penicillin resistance in an international Streptococcus pneumoniae serotype 19F clone emerging in Switzerland was characterized by mutations in the penicillin-binding protein PBP2x. Some isolates of this clone had evolved to higher resistance levels (penicillin MICs of 0.094 and 1 µg/ml), probably by acquisition of pbp2x fragments from local nonencapsulated pneumococci.

* Corresponding author. Mailing address: Institute for Infectious Diseases, University of Berne, Friedbühlstrasse 51, CH-3010 Berne, Switzerland. Phone: 41 31 632 32 59. Fax: 41 31 632 87 66. E-mail: kathrin.muehlemann{at}ifik.unibe.ch.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3563-3566, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3563-3566.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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