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Antimicrobial Agents and Chemotherapy, September 2004, p. 3567-3569, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3567-3569.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

T2182C Mutation in 23S rRNA Is Associated with Clarithromycin Resistance in Helicobacter pylori Isolates Obtained in Bangladesh

Rasel Khan,1 Shamsun Nahar,1 Jinath Sultana,1 Mian Mashhud Ahmad,2 and Motiur Rahman1*

Laboratory Sciences Division, ICDDR, B: Centre for Health and Population Research,1 Dhaka Medical College Hospital, Dhaka, Bangladesh2

Received 25 January 2004/ Returned for modification 5 April 2004/ Accepted 1 May 2004

Twelve clarithromycin-resistant (MIC, ≥1 µg/ml) Helicobacter pylori isolates were analyzed for point mutations in the 23S rRNA gene. Sequence analysis of all of the resistant isolates revealed a T-to-C transition mutation at position 2182. Transformation experiments confirmed that a single T-to-C transition mutation at position 2182 is associated with clarithromycin resistance.

* Corresponding author. Mailing address: Laboratory Sciences Division, ICDDR, B, GPO Box 128, Dhaka 1000, Bangladesh. Phone: 8811751-60. Fax: 880-2-8812529 or -8823116. E-mail: motiur{at}icddrb.org.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3567-3569, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3567-3569.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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