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Antimicrobial Agents and Chemotherapy, September 2004, p. 3570-3572, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3570-3572.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Quinolone-Resistant Haemophilus influenzae in a Long-Term-Care Facility: Nucleotide Sequence Characterization of Alterations in the Genes Encoding DNA Gyrase and DNA Topoisomerase IV

Xinying Li,1 Noriel Mariano,2 James J. Rahal,2 Carl M. Urban,2 and Karl Drlica1*

Public Health Research Institute, Newark, New Jersey,1 Infectious Disease Section, New York Hospital Queens, Flushing, and Department of Microbiology and Medicine, Weill Medical College, Cornell University, New York, New York2

Received 3 February 2004/ Returned for modification 14 April 2004/ Accepted 14 May 2004

Fluoroquinolone-resistant isolates of Haemophilus influenzae, obtained from a long-term care facility, were examined for nucleotide sequence differences in the quinolone-resistance-determining regions of gyrA, gyrB, parC, and parE. Similarities among the resistant isolates, plus multiple differences with susceptible isolates, suggest clonal dissemination involving two resistant subclones.

* Corresponding author. Mailing address: Public Health Research Institute, 225 Warren St., Newark, NJ 07103. Phone: (973) 854-3360. Fax: (973) 854-3101. E-mail: drlica{at}phri.org.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3570-3572, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3570-3572.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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