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Antimicrobial Agents and Chemotherapy, September 2004, p. 3573-3575, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3573-3575.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Lack of Association between Hypermutation and Antibiotic Resistance Development in Pseudomonas aeruginosa Isolates from Intensive Care Unit Patients

Olivia Gutiérrez, Carlos Juan, José L. Pérez, and Antonio Oliver*

Servicio de Microbiología, Hospital Son Dureta, Palma de Mallorca, Spain

Received 17 March 2004/ Returned for modification 28 April 2004/ Accepted 9 May 2004

Hypermutation is a common feature of Pseudomonas aeruginosa isolates from chronically infected cystic fibrosis patients that is linked with antibiotic resistance development. In this work, using a large collection of sequential P. aeruginosa isolates from ICU patients, we found that despite the fact that mutational antibiotic resistance development is a frequent outcome, the prevalence of hypermutable strains is low (found in isolates from only 1 of 103 patients) and there is no evidence of coselection of the hypermutable and antibiotic resistance phenotypes.

* Corresponding author. Mailing address: Servicio de Microbiología, Hospital Son Dureta, C. Andrea Doria No. 55, 07014 Palma de Mallorca, Spain. Phone: 34 971 175 185. Fax: 34 971 175 185. E-mail: aoliver{at}hsd.es.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3573-3575, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3573-3575.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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