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Antimicrobial Agents and Chemotherapy, September 2004, p. 3576-3578, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3576-3578.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Isolation of an Integron-Borne blaVIM-4 Type Metallo-ß-Lactamase Gene from a Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate in Hungary

Balázs Libisch,1* Mária Gacs,1 Károly Csiszár,2 Mónika Muzslay,1 László Rókusz,3 and Miklós Füzi1

Department of Bacteriology, National Center for Epidemiology,1 Department of Internal Medicine, Central Military Hospital, Budapest,3 Laboratory of Bacteriology, Nógrád County Institute of the National Public Health Service, Salgótarján, Hungary2

Received 7 January 2004/ Returned for modification 14 March 2004/ Accepted 11 May 2004

The first integron-borne metallo-ß-lactamase gene was isolated in Hungary. The blaVIM-4 gene is located on a class 1 integron that also carries a novel blaOXA-like gene. The integron is harbored by a serotype O12 Pseudomonas aeruginosa strain and shows high structural similarity to integrons isolated in Greece and Poland.


* Corresponding author. Mailing address: Department of Bacteriology, National Center for Epidemiology, 1097 Budapest, Gyáli út 2-6, Hungary. Phone: 36 1 476 1118. Fax: 36 1 476 1234. E-mail: libischb{at}oek.antsz.hu.


Antimicrobial Agents and Chemotherapy, September 2004, p. 3576-3578, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3576-3578.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.




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