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Antimicrobial Agents and Chemotherapy, September 2004, p. 3636-3639, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3636-3639.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Invasive Streptococcus pneumoniae in France: Antimicrobial Resistance, Serotype, and Molecular Epidemiology Findings from a Monthly National Study in 2000 to 2002

Jean-Winoc Decousser,1* Patrick Pina,2 Florent Viguier,1 Franc Picot,1 Patrice Courvalin,3 Pierre Allouch,1 and the ColBVH Study Group{dagger}

Service d'Hygiène Hospitalière, Centre Hospitalier de Versailles André Mignot, Le Chesnay,1 Service de Médecine B, Hôpital de Plaisir Grignon,2 Unité des Agents Antibactériens, Institut Pasteur, Paris, France3

Received 3 December 2003/ Returned for modification 27 February 2004/ Accepted 1 May 2004

A study of 257 French invasive pneumococci isolated between 2000 and 2002 showed high rates of nonsusceptibility to penicillin and macrolides (50%), contrasting with a low frequency of resistance to amoxicillin or levofloxacin (<1%) and tolerance to vancomycin (0%). The genetic homogeneity of some serogroups, including serogroup 1, enhanced the risk of epidemiological changes.

* Corresponding author. Mailing address: Centre Hospitalier de Versailles André Mignot, Service d'Hygiène Hospitalière, 177 rue de Versailles, 78157 Le Chesnay Cedex, France. Phone: (33) 1 39 63 91 33. Fax: (33) 1 39 63 93 12. E-mail: JWDECOUSSER{at}ch-versailles.fr.

{dagger} Contributing members of the ColBVH Study Group are listed in Acknowledgments.

Antimicrobial Agents and Chemotherapy, September 2004, p. 3636-3639, Vol. 48, No. 9
0066-4804/04/$08.00+0     DOI: 10.1128/AAC.48.9.3636-3639.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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