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Antimicrobial Agents and Chemotherapy, January 2005, p. 408-413, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.408-413.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Comparative In Vitro Activities of XRP 2868, Pristinamycin, Quinupristin-Dalfopristin, Vancomycin, Daptomycin, Linezolid, Clarithromycin, Telithromycin, Clindamycin, and Ampicillin against Anaerobic Gram-Positive Species, Actinomycetes, and Lactobacilli

Ellie J. C. Goldstein,1,2* Diane M. Citron,1 C. Vreni Merriam,1 Yumi A. Warren,1 Kerin L. Tyrrell,1 Helen T. Fernandez,1 and Andre Bryskier3

R. M. Alden Research Laboratory, Santa Monica,1 UCLA School of Medicine, Los Angeles, California,2 Aventis Pharmaceuticals, Romainville, France3

Received 30 May 2004/ Returned for modification 31 August 2004/ Accepted 25 September 2004

A comparative study of the in vitro activities of XRP 2868, a new oral streptogramin, against 266 anaerobic gram-positive clinical isolates using the agar dilution method showed that the XRP 2868 MICs for 95% (254 of 266) of isolates were ≤0.5 µg/ml. XRP 2868 MICs for only two strains, one being Clostridium clostridioforme (MIC, 16 µg/ml) and the other being Clostridium difficile (MIC, 32 µg/ml), were >2 µg/ml. Depending on its pharmacokinetics and pharmacodynamics, XRP 2868 has potential for use against infections with gram-positive anaerobes and deserves further clinical evaluation.

* Corresponding author. Mailing address: 2021 Santa Monica Blvd., Suite 740 East, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: ejcgmd{at}aol.com.

Antimicrobial Agents and Chemotherapy, January 2005, p. 408-413, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.408-413.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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