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Antimicrobial Agents and Chemotherapy, January 2005, p. 428-430, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.428-430.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

In Vivo Resistance of a Laboratory-Selected Aspergillus fumigatus Isolate to Amphotericin B

Elias K. Manavathu,* Jessica L. Cutright, and Pranatharthi H. Chandrasekar

Division of Infectious Diseases, Department of Internal Medicine, Wayne State University, Detroit, Michigan

Received 31 March 2004/ Returned for modification 13 May 2004/ Accepted 16 September 2004

The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.

* Corresponding author. Mailing address: 427 Lande Building, Wayne State University, 550 E. Canfield, Detroit, MI 48201. Phone: (313) 577-1931. Fax: (313) 993-0302. E-mail: aa1388{at}wayne.edu.

Antimicrobial Agents and Chemotherapy, January 2005, p. 428-430, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.428-430.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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