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Antimicrobial Agents and Chemotherapy, January 2005, p. 431-433, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.431-433.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Interaction of Bismuth Subsalicylate with Fruit Juices, Ascorbic Acid, and Thiol-Containing Substrates To Produce Soluble Bismuth Products Active against Clostridium difficile

D. E. Mahony,1* A. Woods,1 M. D. Eelman,2 N. Burford,2 and S. J. O. Veldhuyzen van Zanten3

Departments of Microbiology and Immunology,1 Chemistry,2 Medicine, Dalhousie University, Halifax, Nova Scotia, Canada3

Received 12 May 2004/ Returned for modification 31 August 2004/ Accepted 25 September 2004

Bismuth subsalicylate (BSS), the active ingredient of Pepto-Bismol, has been used for many years to treat various disorders of the gastrointestinal tract. Using mass spectrometry and the agar dilution method, we determined that insoluble BSS interacts with certain dietary components and organic substrates to produce water-soluble products with activity against Clostridium difficile.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7. Phone: (902) 494-3888. Fax: (902) 494-5125. E-mail: David.E.Mahony{at}Dal.Ca.

Antimicrobial Agents and Chemotherapy, January 2005, p. 431-433, Vol. 49, No. 1
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.1.431-433.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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