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Antimicrobial Agents and Chemotherapy, October 2005, p. 4358-4361, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4358-4361.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effect of Amphotericin B on Capsule and Cell Size in Cryptococcus neoformans during Murine Infection

Oscar Zaragoza,1 Coralia Mihu,2,{dagger} Arturo Casadevall,1,2 and Joshua D. Nosanchuk2*

Departments of Microbiology and Immunology,1 Medicine, Albert Einstein College of Medicine, Bronx, New York2

Received 8 June 2005/ Returned for modification 5 July 2005/ Accepted 20 July 2005

Antifungal drugs can affect the cellular morphology of Cryptococcus neoformans in culture, which alters its interactions with phagocytes. We examined the effects of amphotericin B on C. neoformans during murine infection. The antifungal reduced capsule size and serum polysaccharide, which suggests an additional mechanism for amphotericin B's efficacy in cryptococcosis.

* Corresponding author. Mailing address: Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461. Phone: (718) 430-2366. Fax: (718) 430-8968. E-mail: nosanchu{at}aecom.yu.edu.

{dagger} Present address: Memorial Sloan-Kettering Cancer Center, New York, New York 10021.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4358-4361, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4358-4361.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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