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Antimicrobial Agents and Chemotherapy, October 2005, p. 4393-4395, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4393-4395.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Limited Polymorphism in the Dihydropteroate Synthetase Gene (dhps) of Plasmodium vivax Isolates from Thailand

Mallika Imwong,1 Sasithon Pukrittayakamee,1 Qin Cheng,2 Catrin Moore,3 Sornchai Looareesuwan,1 Georges Snounou,4 Nicholas J. White,1,3* and Nicholas P. J. Day1,3

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand,1 Drug Resistance and Diagnostics Department, Australian Army Malaria Institute, Brisbane, Queensland, Australia,2 Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, United Kingdom,3 Unité de Parasitologie Biomédicale, CNRS URA 2581, Institut Pasteur, Paris, France4

Received 30 March 2005/ Returned for modification 12 May 2005/ Accepted 21 July 2005

The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A -> G) in 33 isolates, all from Thailand. Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.

* Corresponding author. Mailing address: Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd., Bangkok 10400, Thailand. Phone: 66 2 354 9172. Fax: 66 2 354 9169. E-mail: nickw{at}tropmedres.ac.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4393-4395, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4393-4395.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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