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Antimicrobial Agents and Chemotherapy, October 2005, p. 4406-4409, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4406-4409.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Lower Nitric Oxide Susceptibility of Trivalent Antimony-Resistant Amastigotes of Leishmania infantum

P. Holzmuller, D. Sereno, and J.-L. Lemesre*

UR 008 Pathogénie des Trypanosomatidés, Institut de Recherche pour le Développement, B.P. 64501, 911 Avenue Agropolis, 34394 Montpellier Cédex 5, France

Received 21 March 2005/ Returned for modification 25 April 2005/ Accepted 30 June 2005

We previously documented the induction of Leishmania amastigote apoptosis by trivalent antimony (SbIII) and nitric oxide (NO). We demonstrate here that SbIII-resistant amastigotes were resistant to NO toxicity when delivered extracellularly by NO donors or intracellularly via macrophage activation. Shared biochemical targets for SbIII and NO resistance in Leishmania are discussed.

* Corresponding author. Mailing address: UR 008 Pathogénie des Trypanosomatidés, IRD (Institut de Recherche pour le Développement), B.P. 64501, 911 avenue Agropolis, 34394 Montpellier Cédex 5, France. Phone: 33 (0)4 67 41 62 20. Fax: 33 (0)4 67 41 63 30. E-mail: lemesre{at}mpl.ird.fr.

Antimicrobial Agents and Chemotherapy, October 2005, p. 4406-4409, Vol. 49, No. 10
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.10.4406-4409.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Luque-Ortega, J. R., Rivas, L. (2007). Miltefosine (Hexadecylphosphocholine) Inhibits Cytochrome c Oxidase in Leishmania donovani Promastigotes. Antimicrob. Agents Chemother. 51: 1327-1332 [Abstract] [Full Text]  
  • Ashutosh, , Sundar, S., Goyal, N. (2007). Molecular mechanisms of antimony resistance in Leishmania. J Med Microbiol 56: 143-153 [Abstract] [Full Text]  


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