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Antimicrobial Agents and Chemotherapy, November 2005, p. 4667-4670, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4667-4670.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Virulence Factors of Escherichia coli Isolates That Produce CTX-M-Type Extended-Spectrum ß-Lactamases

Departments of Pathology and Laboratory Medicine,¹ Microbiology and Infectious Diseases,² Medicine,³ Critical Care Medicine, University of Calgary,⁴ Division of Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada,⁵ Mucosal and Vaccine Research Center, Veterans Affairs Medical Center,⁶ Department of Medicine, University of Minnesota, Minneapolis, Minnesota⁷

Received 22 June 2005/ Returned for modification 12 August 2005/ Accepted 19 August 2005

This study determined the phylogenetic groups and virulence factors of 37 Escherichia coli isolates producing types of CTX-M compared with those of 19 isolates producing different types of extended-spectrum ß-lactamases (ESBLs) in a well-defined North American population. Most CTX-M-14 producers (97%) were from phylogenic group D; 67% of the CTX-M-15 producers were from group B2. A single CTX-M-14-producing strain belonged to clonal group A. There were significant prevalence differences for individual virulence factors among CTX-M producers and nonproducers; however, aggregate virulence factor scores were similar. CTX-M producers more commonly caused repeat urinary tract infections. Our results indicate that CTX-M type predicts phylogenetic background, and the virulence potential of ESBL-producing E. coli isolates is a complex issue, requiring further study and ongoing surveillance.

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