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Antimicrobial Agents and Chemotherapy, November 2005, p. 4754-4756, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4754-4756.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Increased Mutation Frequencies in Escherichia coli Isolates Harboring Extended-Spectrum ß-Lactamases

María-Rosario Baquero, Juan Carlos Galán, María del Carmen Turrientes, Rafael Cantón, Teresa M. Coque, José Luis Martínez, and Fernando Baquero*

Department of Microbiology, Ramón y Cajal University Hospital, and Centro Nacional de Biotecnología (CSIC-RYC Associated Unit on Antibiotic Resistance and Bacterial Virulence), 28034 Madrid, Spain

Received 27 April 2005/ Returned for modification 6 July 2005/ Accepted 16 August 2005

Hypermutable (mutation frequency [f], ≥4 x 10–8) Escherichia coli strains were more frequently found (43%) in a collection of 89 extended-spectrum ß-lactamase (ESBL)-producing isolates from different patients (77 pulsed-field gel electrophoresis clones, 12 ESBL types) than in non-ESBL E. coli (26%) strains (P = 0.03). Among urinary tract isolates, the frequency of hypermutation was 40% in ESBL versus 26% in non-ESBL isolates (P = 0.03).

* Corresponding author. Mailing address: Department of Microbiology, Ramón y Cajal University Hospital, Ctra. de Colmenar, Km 9,1, 28034 Madrid, Spain. Phone: 34-91-3368330. Fax: 34-91-3368809. E-mail: fbaquero.hrc{at}salud.madrid.org.

Antimicrobial Agents and Chemotherapy, November 2005, p. 4754-4756, Vol. 49, No. 11
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.11.4754-4756.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ellington, M. J., Livermore, D. M., Pitt, T. L., Hall, L. M. C., Woodford, N. (2006). Mutators among CTX-M {beta}-lactamase-producing Escherichia coli and risk for the emergence of fosfomycin resistance. J Antimicrob Chemother 58: 848-852 [Abstract] [Full Text]  
  • Hall, L. M. C., Henderson-Begg, S. K. (2006). Hypermutable bacteria isolated from humans - a critical analysis.. Microbiology 152: 2505-2514 [Abstract] [Full Text]  


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