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Antimicrobial Agents and Chemotherapy, December 2005, p. 5139-5141, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5139-5141.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Caspofungin and Liposomal Amphotericin B Therapy of Experimental Murine Scedosporiosis

Rosie Bocanegra,* Laura K. Najvar, Steve Hernandez, Dora I. McCarthy, and John R. Graybill

The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900

Received 17 June 2005/ Returned for modification 2 August 2005/ Accepted 12 September 2005

Immunosuppressed mice were infected intravenously with conidia of Scedosporium prolificans. Treatment was begun 1 day later with liposomal amphotericin B, caspofungin, or both drugs initiated concurrently. Amphotericin B and caspofungin were each effective, but combined therapy did not appear to offer advantages over liposomal amphotericin B alone.

* Corresponding author. Mailing address: The University of Texas Health Science Center at San Antonio, Department of Medicine/Division of Infectious Diseases (MC 7881), 7703 Floyd Curl Drive, San Antonio, TX 78229-3900. Phone: (210) 567-0990. Fax: (210) 567-0962. E-mail: Bocanegra{at}uthscsa.edu.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5139-5141, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5139-5141.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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