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Antimicrobial Agents and Chemotherapy, December 2005, p. 5153-5156, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5153-5156.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

VIM-12, a Novel Plasmid-Mediated Metallo-ß-Lactamase from Klebsiella pneumoniae That Resembles a VIM-1/VIM-2 Hybrid

Spyros Pournaras,1* Alexandros Ikonomidis,1 Leonidas S. Tzouvelekis,2 Despoina Tokatlidou,3 Nicholas Spanakis,2 Antonios N. Maniatis,1 Nicholas J. Legakis,2 and Athanassios Tsakris2

Department of Microbiology, Medical School, University of Thessaly, Larissa,1 Department of Microbiology, Medical School, University of Athens, Athens,2 Department of Microbiology, Hippokration General Hospital, Thessaloniki, Greece3

Received 27 July 2005/ Returned for modification 6 September 2005/ Accepted 30 September 2005

A transferable plasmid from Klebsiella pneumoniae carried a class 1 integron containing blaVIM-12, a novel blaVIM-type gene, flanked by two copies of aacA7. blaVIM-12 was clustered between blaVIM-1 and blaVIM-2 and differed from blaVIM-1 by 18 nucleotides that were all located at the 3' end and matched the corresponding nucleotides in blaVIM-2. The blaVIM-12-associated 59-base element was identical to that described in blaVIM-2 alleles.

* Corresponding author. Mailing address: Department of Medical Microbiology, University Hospital of Larissa, Mezourlo, 411 10 Larissa, Greece. Phone: 30-6976-881203. Fax: 30-24210-76650. E-mail: pournaras{at}med.uth.gr.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5153-5156, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5153-5156.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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