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Antimicrobial Agents and Chemotherapy, December 2005, p. 5157-5159, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5157-5159.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Effect of Voriconazole Combined with Micafungin against Candida, Aspergillus, and Scedosporium spp. and Fusarium solani

Kathrin Heyn, Antje Tredup, Stefanie Salvenmoser, and Frank-Michael C. Müller*

Department of Pediatrics III, Pediatric Pulmonology and Infectious Diseases, University of Heidelberg, Im Neuenheimer Feld 153, D-69120 Heidelberg, Germany

Received 14 June 2005/ Returned for modification 2 August 2005/ Accepted 23 September 2005

Effects of voriconazole combined with micafungin against 101 isolates of Candida spp. and 100 isolates of filamentous fungi have been evaluated by in vitro checkerboard analysis. The combination was indifferent for 97% of the Candida isolates and synergistic for 64% of the filamentous fungi (79% for Aspergillus fumigatus).

* Corresponding author. Mailing address: Pediatric Pulmonology and Infectious Diseases, Im Neuenheimer Feld 153, D-69120 Heidelberg, Germany. Phone: 49-6221-56-8356. Fax: 49-6221-56-33853. E-mail: Frank-Michael_Mueller{at}med.uni-heidelberg.de.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5157-5159, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5157-5159.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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