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Antimicrobial Agents and Chemotherapy, December 2005, p. 5160-5161, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5160-5161.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

A Cysteine Protease Inhibitor Protects Dogs from Cardiac Damage during Infection by Trypanosoma cruzi

S. C. Barr,1 K. L. Warner,1 B. G. Kornreic,1 J. Piscitelli,2 A. Wolfe,3 L. Benet,3 and J. H. McKerrow4*

Department of Clinical Sciences, Cornell University School of Veterinary Medicine, Ithaca, New York 14850,1 Department of Clinical Pathology, Albert Einstein College of Medicine, Bronx, New York 10461,2 Department of Biopharmaceutical Science, University of California, San Francisco, California 94122,3 Department of Pathology, University of California, San Francisco, California 941224

Received 19 August 2005/ Returned for modification 27 August 2005/ Accepted 27 September 2005

Cruzain is an essential cysteine protease of Trypanosoma cruzi and a therapeutic target for Chagas' disease. Eight dogs were infected with T. cruzi; three were treated with an inhibitor of cruzain, K777, for 14 days. Treatment with K777 abrogated myocardial damage by T. cruzi, as documented by histopathological lesion scores and serum troponin I levels.

* Corresponding author. Mailing address: University of California, San Francisco, QB3 508, San Francisco, CA 94143-2550. Phone: (415) 476-2940. Fax: (415) 502-8193. E-mail: jmck{at}cgl.ucsf.edu.

Antimicrobial Agents and Chemotherapy, December 2005, p. 5160-5161, Vol. 49, No. 12
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.12.5160-5161.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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