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Antimicrobial Agents and Chemotherapy, February 2005, p. 497-502, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.497-502.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Efficacy of Micafungin in Combination with Other Drugs in a Murine Model of Disseminated Trichosporonosis

Carolina Serena, F. Javier Pastor, Félix Gilgado, Emilio Mayayo, and Josep Guarro*

Unitat de Microbiologia, Facultat de Medicina i Ciencies de la Salut, Universitat Rovira i Virgili, Reus, Spain

Received 1 September 2004/ Returned for modification 8 September 2004/ Accepted 25 September 2004

Using a murine model of disseminated infection caused by Trichosporon asahii, we have evaluated the efficacies of amphotericin B (AMB; 1 mg/kg of body weight/day), fluconazole (FLC; 20 mg/kg/twice a day), and micafungin (MFG; 5 mg/kg/twice a day). We tested these drugs alone and in combination (MFG with AMB and MFG with FLC). MFG with AMB showed a synergistic effect and demonstrated a higher degree of efficacy in prolonging survival and reducing the kidney fungal burden than either agent alone. The combination MFG with FLC was able to reduce significantly the kidney fungal burden in comparison to that achieved with either drug administered alone.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili. Carrer Sant Llorenç, 21 43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: jga{at}fmcs.urv.es.

Antimicrobial Agents and Chemotherapy, February 2005, p. 497-502, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.497-502.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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