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Antimicrobial Agents and Chemotherapy, February 2005, p. 779-780, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.779-780.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Interspecies Recombination in Type II Topoisomerase Genes Is Not a Major Cause of Fluoroquinolone Resistance in Invasive Streptococcus pneumoniae Isolates in the United States

Mathias W. R. Pletz,1,2* Lesley McGee,1,2 Bernard Beall,2 Cynthia G. Whitney,2 and Keith P. Klugman1,2

Department of International Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University,1 Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia2

Received 17 August 2004/ Returned for modification 11 October 2004/ Accepted 13 October 2004

Mutations in the topoisomerase type II enzymes account for fluoroquinolone resistance in Streptococcus pneumoniae. These mutations can arise spontaneously or be transferred by intraspecies or interspecies recombination, primarily with viridans streptococci. We analyzed the nucleotide sequences of the quinolone resistance-determining regions of 49 invasive levofloxacin-resistant pneumococcal isolates and did not find any evidence for interspecies recombination.

* Corresponding author. Mailing address: Department of International Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd., Atlanta, GA 30322. Phone: (404) 727-3984. Fax: (404) 712-8419. E-mail: mpletz{at}sph.emory.edu.

Antimicrobial Agents and Chemotherapy, February 2005, p. 779-780, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.779-780.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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