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Antimicrobial Agents and Chemotherapy, February 2005, p. 788-790, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.788-790.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibility Survey of Streptococcus pyogenes Isolated in Japan from Patients with Severe Invasive Group A Streptococcal Infections

Tadayoshi Ikebe,1* Kyoko Hirasawa,2 Rieko Suzuki,3 Junko Isobe,4 Daisuke Tanaka,4 Chihiro Katsukawa,5 Ryuji Kawahara,5 Masaaki Tomita,6 Kikuyo Ogata,7 Miyoko Endoh,8 Rumi Okuno,8 Haruo Watanabe,1 and the Working Group for Group A Streptococci in Japan{dagger}

Department of Bacteriology, National Institute of Infectious Diseases,1 Department of Bacteriology, Tokyo Metropolitan Institute of Public Health, Tokyo,8 Department of Bacteriology, Fukushima Prefectural Institute of Public Health, Fukushima,2 Department of Microbiology, Kanagawa Prefectural Public Health Laboratory, Kanagawa,3 Department of Bacteriology, Toyama Institute of Health, Toyama,4 Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka,5 Division of Biological Medicine, Yamaguchi Prefectural Research Institute of Public Health, Yamaguchi,6 Department of Bacteriology, The Oita Prefectural Institute of Health and Environment, Oita, Japan7

Received 24 June 2004/ Returned for modification 26 September 2004/ Accepted 11 October 2004

We assessed antimicrobial susceptibility against 211 Streptococcus pyogenes strains isolated from patients with severe invasive group A streptococcal infections. Overall, 3.8, 1.4, 1.4, and 0.5% of the isolates were resistant to erythromycin, clindamycin, telithromycin, and ciprofloxacin, respectively, and 10.4% had intermediate resistance to ciprofloxacin. All isolates were susceptible to ampicillin and cefotaxime.

* Corresponding author. Mailing address: Department of Bacteriology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan. Phone and fax: 81-3-5285-1171. E-mail: haruwata{at}nih.go.jp.

{dagger} Members of the Working Group for Group A Streptococci in Japan are listed in Acknowledgments.

Antimicrobial Agents and Chemotherapy, February 2005, p. 788-790, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.788-790.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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