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Antimicrobial Agents and Chemotherapy, February 2005, p. 853-856, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.853-856.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Modeling In Vivo Pharmacokinetics and Pharmacodynamics of Moxifloxacin Therapy for Mycobacterium tuberculosis Infection by Using a Novel Cartridge System

Amy Sarah Ginsburg,1 Jin Lee,2,{dagger} Samuel C. Woolwine,1 Jacques H. Grosset,1 Fayez M. Hamzeh,2,{ddagger} and William R. Bishai1*

Departments of Medicine,1 Pharmacology, Johns Hopkins School of Medicine, Baltimore, Maryland2

Received 21 May 2004/ Returned for modification 27 July 2004/ Accepted 27 September 2004

To study the efficacy of moxifloxacin treatment for tuberculosis, we utilized a novel cartridge system to simulate in vivo pharmacokinetics. We found this system to be a robust method for modeling in vivo pharmacokinetics and present data supporting the utility of intermittent moxifloxacin treatment as a component of antituberculosis chemotherapy.

* Corresponding author. Mailing address: 1503 East Jefferson St., Room 112, Baltimore, MD 21231-1001. Phone: (410) 955-3507. Fax: (410) 614-8173. E-mail: wbishai{at}jhmi.edu.

{dagger} Present address: Department of Epidemiology, Bloomberg School of Public Health, Baltimore, MD 21287.

{ddagger} Present address: Roche Laboratories Inc., Nutley, NJ 07110-1199.

Antimicrobial Agents and Chemotherapy, February 2005, p. 853-856, Vol. 49, No. 2
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.2.853-856.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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