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Antimicrobial Agents and Chemotherapy, March 2005, p. 1201-1202, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1201-1202.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Activity of Cathelicidin Peptides against Chlamydia spp.

Manuela Donati,1 Korinne Di Leo,1 Monica Benincasa,2 Francesca Cavrini,1 Silvia Accardo,1 Alessandra Moroni,1 Renato Gennaro,2 and Roberto Cevenini1*

Sezione di Microbiologia, DMCSS, Policlinico S. Orsola, University of Bologna, Bologna,1 Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, Trieste, Italy2

Received 15 July 2004/ Returned for modification 29 August 2004/ Accepted 31 October 2004

The in vitro activity of six cathelicidin peptides against 25 strains of Chlamydia was investigated. SMAP-29 proved to be the most active peptide, reducing the inclusion numbers of all 10 strains of Chlamydia trachomatis tested by ≥50% at 10 µg/ml. This peptide was also active against C. pneumoniae and C. felis.

* Corresponding author. Mailing address: Sezione di Microbiologia, DMCSS, Policlinico S.Orsola, Università di Bologna, Via Massarenti 9, 40138 Bologna, Italy. Phone: 39 0514290910. Fax: 39 051307397. E-mail: roberto.cevenini{at}unibo.it.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1201-1202, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1201-1202.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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