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Antimicrobial Agents and Chemotherapy, March 2005, p. 1203-1205, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1203-1205.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antimicrobial Susceptibility of Shigella sonnei Isolates in Japan and Molecular Analysis of S. sonnei Isolates with Reduced Susceptibility to Fluoroquinolones

Kenji Hirose,1* Jun Terajima,1 Hidemasa Izumiya,1 Kazumichi Tamura,1 Eiji Arakawa,1 Nobuko Takai,1 and Haruo Watanabe1

Department of Bacteriology, National Institute of Infectious Diseases., Shinjuku, Tokyo, Japan1

Received 16 July 2004/ Returned for modification 17 September 2004/ Accepted 11 November 2004

We performed susceptibility testing with Shigella sonnei isolates from imported and domestic cases of infection in Japan during 2001 and 2002. Some S. sonnei isolates were resistant to nalidixic acid, tetracycline, and trimethoprim-sulfamethoxazole. Most of the nalidixic acid-resistant strains showed reduced susceptibility to fluoroquinolones but did not show fluoroquinolone resistance.

* Corresponding author. Mailing address: Department of Bacteriology, National Institute of Infectious Diseases., 1-23-1-Toyama, Shinjuku, Tokyo 162-8640, Japan. Phone: 81-3-5285-1111, ext. 2230. Fax: 81-3-5285-1163. E-mail: hirosek{at}nih.go.jp.

Antimicrobial Agents and Chemotherapy, March 2005, p. 1203-1205, Vol. 49, No. 3
0066-4804/05/$08.00+0     doi:10.1128/AAC.49.3.1203-1205.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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